Home About Us Government Relations and Advocacy Media Contact Us Site Map Privacy Français  
 
Multiple Sclerosis Society of CanadaSociété canadienne de la sclérose en plaquesfinding a cure - enhancing quality of life
Multiple Sclerosis Living with Multiple Sclerosis Treatments Donate Now Get Involved Special Events

 


Research
    share +

What is the risk of permanent disability from a multiple sclerosis relapse?

View or print this bulletin in its original format.

You will need ADOBE ACROBAT READER to view this document listed above - it's FREE.

Medical Update Memo
June 7, 2010

Summary

Authors report on how often patients with relapsing-remitting multiple sclerosis (MS) develop severe (Expanded Disability Status Scale [EDSS]  of 6.0 or greater) sustained (greater than 6 months) disability due to an acute relapse. Khemissa Bejaoui, PhD; Loren A. Rolak, MD Neurology® 2010;74:900–902

Details

Authors aimed to establish the risk of permanent disability from an MS relapse and determine whether high-risk patients can be identified in advance, the outcomes of all relapses in patients seen in a specialized MS clinic were analyzed. Data on relapses was collected prospectively since 1994.
 
Among the 1,078 patients in the Marshfield Multiple Sclerosis Center, there were 2,587 relapses (mean of 2.4 per patient, with a range of 1–11 attacks over 1–15 years). Only 7 patients had a relapse resulting in EDSS 6 or greater that did not recover. Genetic analysis showed no difference in HLA-DR or NOS2A loci between these patients and other MS populations, nor were there any clinical factors that identified high risk. Two of these patients were on interferon treatment at the time of their disabling attack.

Authors conclude that the fear of a sudden irreversible disability should not influence therapeutic decisions because such attacks are very rare and can occur whether or not patients are treated with interferons.

 

National Research and Programs
Offert en français.


share +

Disclaimer
The Multiple Sclerosis Society of Canada is an independent, voluntary health agency and does not approve, endorse or recommend any specific product or therapy, but provides information to assist individuals in making their own decisions.

Back to top

line
Charitable registration
10774 6174 RR0001
Multiple Sclerosis Society of Canada
Toll free to reach the nearest regional office: 1 800 268-7582

To locate the MS Society office near you, please select your region:

E-mail: info@mssociety.ca
(Please provide your town and province in your e-mail)

Multiple Sclerosis   Living with MS   Research   Treatments   Donate Now   Get Involved    Special Events

Home    About Us    Advocacy    Media    Contact Us    Site Map    Privacy    Français